{"id":43741,"date":"2024-04-01T00:28:21","date_gmt":"2024-03-31T23:28:21","guid":{"rendered":"https:\/\/ub-blog.meduniwien.ac.at\/blog\/?p=43741"},"modified":"2024-03-19T10:28:55","modified_gmt":"2024-03-19T09:28:55","slug":"gastautor-prof-dr-peter-heilig-neuromagie-und-unfaelle-2-2-2-2-3-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-3-2-3-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-3-3-2-3","status":"publish","type":"post","link":"https:\/\/ub.meduniwien.ac.at\/blog\/?p=43741","title":{"rendered":"Gastautor Prof. Dr. Peter Heilig: Vogel-Strauss-Politik"},"content":{"rendered":"

Die Frage lautet, wann<\/strong> eine neue Pandemie droht – nicht ob.. (1)<\/p>\n

WHO<\/strong>:<\/p>\n

Antimicrobial resistance (AMR) is one of the top global public health and development threats. It is estimated that bacterial AMR was directly responsible for 1.27 million global deaths in 2019 and contributed to 4.95 million deaths.<\/p>\n

The misuse and overuse of antimicrobials in humans, animals and plants are the main drivers in the development of drug-resistant pathogens.<\/p>\n

\"\"<\/a><\/p>\n

AMR affects countries in all regions and at all income levels. Its drivers and consequences are exacerbated by poverty and inequality, and low- and middle-income countries are most affected.<\/p>\n

AMR puts many of the gains of modern medicine at risk. It makes infections harder to treat and makes other medical procedures and treatments \u2013 such as surgery, caesarean sections and cancer chemotherapy \u2013 much riskier.<\/p>\n

The world faces an antibiotics pipeline and access crisis. There is an inadequate research and development pipeline in the face of rising levels of resistance, and urgent need for additional measures to ensure equitable access to new and existing vaccines, diagnostics and medicines.<\/p>\n

In addition to death and disability, AMR has significant economic costs.<\/p>\n

https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/antimicrobial-resistance<\/p>\n

Resistenzen: Heilig P (2024)
\nhttps:\/\/ub-blog.meduniwien.ac.at\/blog\/?p=43031<\/a><\/p>\n

Prophylaxe und Strategien<\/p>\n

Globale, rechtlich verbindliche Vereinbarungen sind zu treffen um k\u00fcnftige Pandemie- Katastrophen zu vermeiden \u2013 erste Schritte..<\/p>\n

https:\/\/www.who.int\/news\/item\/03-03-2023-countries-begin-negotiations-on-global-agreement-to-protect-world-from-future-pandemic-emergencies<\/p>\n

– mit konkreten Vorstellungen: \u201cSix specific, politically feasible mechanisms for new international agreements that, together, could create compliance pressures to shift state behaviour.\u201c<\/em><\/p>\n

\"\"<\/a><\/p>\n

Kavanagh MM et al (2023) Increasing compliance with international pandemic law: international relations and new global health agreements. Lancet 23;402(10407):1097-1106.<\/p>\n

\u201eHuman survival depends on biodiversity.\u201c <\/em>Jane Goodall<\/p>\n

Heilig P (2022) https:\/\/ub-blog.meduniwien.ac.at\/blog\/?p=39112<\/p>\n

Neu zu schaffende Fr\u00fchwarn-Einrichtungen f\u00fcr neue Erkrankungen (‚Disease X‘) werden dringend ben\u00f6tigt (2). Flexibilit\u00e4t ist gefragt (3).<\/p>\n

Clostridioides difficile – \u201ca New „Superbug“<\/em>, weltweit verbreitet, mit hohen Rezidiv- und Mortalit\u00e4tsraten, multiresistent, wurde zu einem besorgniserregenden Problem (4). Neue Behandlungsmethoden m\u00fcssen dringend entwickelt werden (5), auch neue Diagnose-Armamentarien, z.B. \u201cBacteria-binding peptides (BBPs) in combination with horseradish peroxidase (HRP)\u201c etc.<\/em><\/p>\n

\"\"<\/a><\/p>\n

Neue Wege m\u00fcssen beschritten werden: \u201cTechnological advances in gene sequencing and computing have led to an explosion in the availability of bioinformatic data and processing power, respectively, creating a ripe nexus for artificial intelligence (AI) to design strategies for controlling cell behavior.\u201c<\/em><\/p>\n

https:\/\/news.northwestern.edu\/stories\/2024\/03\/transfer-learning-paves-the-way-for-new-disease-treatments\/<\/em><\/p>\n

In der Diagnostik k\u00f6nnen AI-Modelle hilfreich sein, speziell in Verbindung mit dem ‚black box‘-Problem.<\/p>\n

\"\"<\/a><\/p>\n

https:\/\/beckman.illinois.edu\/about\/news\/article\/2024\/03\/04\/new-ai-model-draws-treasure-maps-to-diagnose-disease<\/p>\n

 <\/em>Keinesfalls darf au\u00dfer Acht gelassen werden, dass scheinbar allwissenden AI-Systeme Bias-anf\u00e4llig sind und dass dieses Problem zur neuen Herausforderung wurde (6)<\/p>\n

\u201cAI is no panacea, of course. Like all powerful technologies, it presents risks as well as benefits\u201c https:\/\/online.sse.tulane.edu\/articles\/can-ai-prevent-the-next-pandemic-tulane-mscs\/. <\/em>Ein Werkzeug, aber nicht mehr: AI can be a valuable tool for the development of public health policy. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10637620\/<\/em><\/p>\n

\"\"<\/a><\/p>\n

Epilog: Nicht als unverbindliche WHO-Empfehlung sind oben skizzierte l\u00e4ngst \u00fcberf\u00e4llige Ma\u00dfnahmen zu verstehen  – allzu lange wurde der ‚Kopf in den Sand‘<\/em> gesteckt.<\/p>\n

1 Correction for Marani et al., Intensity and frequency of extreme novel epidemics. Proc<\/p>\n

 Natl Acad Sci U S A. 2023 Mar 21;120(12):e2302169120.<\/p>\n

2 Disease X: WHO Warns Future Outbreak Just a Matter of Time : ScienceAlert<\/a><\/p>\n

3 Manirambona E et al (2024) Mitigating the threat of „Disease X“ to global health security. New Microbes New Infect;57:101223<\/p>\n

4 Markovska R et al (2023) Clostridioides difficile<\/em>, a New „Superbug“. Microorganisms;11 (4):845 5 Gurung B et al (2024) Gut Microbiota-Gut Metabolites and Clostridioides difficile<\/em> Infection: Approaching Sustainable Solutions for Therapy. Metabolites;14(1):74.  6 Mittermaier M et al (2023) Bias in AI-based models for medical applications: challenges nd mitigation strategies. npj Digit. <\/em>Med.<\/em> 6, 113 .<\/p>\n

Gender: beyond<\/p>\n

Interest: no conflict<\/p>\n

*************************<\/p>\n

Veranstaltung:<\/p>\n

UV-Strahlung. Freund oder Feind?<\/strong><\/p>\n

Mittwoch, 10. April 2024, 19:00 Uhr<\/p>\n

Weitere Infos\u2013>Einladung UV-Strahlung  PDF<\/a><\/p>\n

*************************<\/p>\n

Interessenkonflikt:
\nDer Autor erkl\u00e4rt, dass bei der Erstellung
\ndes Beitrags kein Interessen \u2013
\nkonflikt im Sinne der Empfehlung des
\nInternational Committee of Medical
\nJournal Editors bestand.<\/p>\n

Korrespondenzadresse:
\nUniv.-Prof. Dr. med. Peter Heilig
\nAugenheilkunde und Optometrie
\npeter.heilig@univie.ac.at<\/p>\n

Weitere Beitr\u00e4ge \u00bb<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Die Frage lautet, wann eine neue Pandemie droht – nicht ob.. (1) WHO: Antimicrobial resistance (AMR) is one of the top global public health and development threats. It is estimated that bacterial AMR was directly responsible for 1.27 million global deaths in 2019 and contributed to 4.95 million deaths. The misuse and overuse of antimicrobials … Gastautor Prof. Dr. Peter Heilig: Vogel-Strauss-Politik<\/span> weiterlesen →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[1,33,2,16],"tags":[],"class_list":["post-43741","post","type-post","status-publish","format-standard","hentry","category-allgemeines","category-gastbeitrage","category-news","category-news1"],"views":1319,"_links":{"self":[{"href":"https:\/\/ub.meduniwien.ac.at\/blog\/index.php?rest_route=\/wp\/v2\/posts\/43741","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ub.meduniwien.ac.at\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ub.meduniwien.ac.at\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ub.meduniwien.ac.at\/blog\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ub.meduniwien.ac.at\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=43741"}],"version-history":[{"count":4,"href":"https:\/\/ub.meduniwien.ac.at\/blog\/index.php?rest_route=\/wp\/v2\/posts\/43741\/revisions"}],"predecessor-version":[{"id":43751,"href":"https:\/\/ub.meduniwien.ac.at\/blog\/index.php?rest_route=\/wp\/v2\/posts\/43741\/revisions\/43751"}],"wp:attachment":[{"href":"https:\/\/ub.meduniwien.ac.at\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=43741"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ub.meduniwien.ac.at\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=43741"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ub.meduniwien.ac.at\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=43741"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}